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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 404065Generated: October 25, 2026

Methyl 1-aminocyclobutane-1-carboxylate hydrochloride → Methyl 1-(6-(4-nitrophenyl)-1-oxoisoindolin-2-yl)cyclobutanecarboxylate

https://huagongshe.com/reaction/404065

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethyl 1-aminocyclobutane-1-carboxylate hydrochlorideHCID 42614147—
ReactantMethyl 4-(bromomethyl)-4'-nitrobiphenyl-3-carboxylateHCID 67306641—
Reactant(S)-Methyl 3-methyl-2-(6-(4-nitrophenyl)-1-oxoisoindolin-2-yl)butanoateHCID 131731440—
ProductMethyl 1-(6-(4-nitrophenyl)-1-oxoisoindolin-2-yl)cyclobutanecarboxylateHCID 6731369271%

Reaction Steps

The compound of example 573 was prepared analogous to compound of example 5 by reaction of compound of example 4 with methyl 1-aminocyclobutanecarboxylate hydrochloride.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08748426B2
Source datasetuspto-grants-2014_06
ORD IDord-3299c086db7c4247a596710f1681fa26
Source noteuspto-grants-2014_06