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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 404068Generated: October 25, 2026

(S)-2-(6-(4-Benzamidophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoic acid → 1-(6-(4-(4-Chlorobenzamido)phenyl)-1-oxoisoindolin-2-yl)cyclobutane carboxylic acid

https://huagongshe.com/reaction/404068

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(S)-2-(6-(4-Benzamidophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoic acidHCID 53303631—
ReactantMethyl 1-(6-(4-(4-chlorobenzamido)phenyl)-1-oxoisoindolin-2-yl)cyclobutane carboxylateHCID 70975309—
Product1-(6-(4-(4-Chlorobenzamido)phenyl)-1-oxoisoindolin-2-yl)cyclobutane carboxylic acidHCID 6730645493%

Reaction Steps

The compound of example 578 was prepared analogous to compound of example 98 by hydrolysis of compound of example 577.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08748426B2
Source datasetuspto-grants-2014_06
ORD IDord-a5bc1844a960473c9c839080e54828ce
Source noteuspto-grants-2014_06