Methyl 1-(6-(4-nitrophenyl)-1-oxoisoindolin-2-yl)cyclopropanecarboxylate → Methyl 1-(6-(4-aminophenyl)-1-oxoisoindolin-2-yl)cyclopropanecarboxylate

HRID 404074Notes

Reaction equation

HRID 404074 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:16]=[C:15]3[C:11]([CH2:12][N:13]([C@@H:18]([CH:23]([CH3:25])C)[C:19]([O:21][CH3:22])=[O:20])[C:14]3=[O:17])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.[N+](C1C=CC(C2C=C3C(CN(C4(C(OC)=O)CC4)C3=O)=CC=2)=CC=1)([O-])=O>>[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:16]=[C:15]3[C:11]([CH2:12][N:13]([C:18]4([C:19]([O:21][CH3:22])=[O:20])[CH2:25][CH2:23]4)[C:14]3=[O:17])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 67313125Methyl 1-(6-(4-nitrophenyl)-1-oxoisoindolin-2-yl)cyclopropanecarboxylateHCID 131731441(S)-Methyl 2-(6-(4-aminophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate

Product 1

HCID 67313175Methyl 1-(6-(4-aminophenyl)-1-oxoisoindolin-2-yl)cyclopropanecarboxylateYield 61%

Procedure

The compound of example 584 was prepared analogous to the compound of example 6 by reduction of the compound of example 583.

Sources & evidence

ORD record
ord-0b765251805b42108f85a315671b773d
Source dataset
uspto-grants-2014_06
Patent number
US08748426B2

Reaction notes

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