HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Trifluoromethyl)benzoyl chloride → 1-(6-(4-(4-Chlorobenzamido)phenyl)-1-oxoisoindolin-2-yl)cyclopropane carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Trifluoromethyl)benzoyl chloride | HCID 67607 | — |
| Reactant | Methyl 1-(6-(4-aminophenyl)-1-oxoisoindolin-2-yl)cyclopropanecarboxylate | HCID 67313175 | — |
| Reactant | (S)-Methyl 2-(6-(4-benzamidophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate | HCID 123625862 | — |
| Product | 1-(6-(4-(4-Chlorobenzamido)phenyl)-1-oxoisoindolin-2-yl)cyclopropane carboxylic acid | HCID 67306366 | 93% |
Reaction Steps
The compound of example 588 was prepared analogous to compound of example 97 by reaction of compound of example 584 with 4-trifluoromethyl benzoyl chloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08748426B2 |
| Source dataset | uspto-grants-2014_06 |
| ORD ID | ord-506a431901b24aec841e2bf3ed7783cd |
| Source note | uspto-grants-2014_06 |