(S)-2-(6-(4-Benzamidophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoic acid → HCID 67305920, compound

HRID 404085Notes

Reaction equation

HRID 404085 reaction equation
C(NC1C=CC(C2C=C3C(CN([C@@H](C(C)C)C(O)=O)C3=O)=CC=2)=CC=1)(=O)C1C=CC=CC=1.[F:33][C:34]1[CH:39]=[C:38]([NH:40][C:41](=[O:53])[C:42]2[CH:47]=[CH:46][C:45]([O:48][C:49]([F:52])([F:51])[F:50])=[CH:44][CH:43]=2)[CH:37]=[CH:36][C:35]=1[C:54]1[CH:62]=[C:61]2[C:57]([CH2:58][N:59]([C@@H:64]([CH:69]([CH3:71])[CH3:70])[C:65]([O:67]C)=[O:66])[C:60]2=[O:63])=[CH:56][CH:55]=1>>[F:33][C:34]1[CH:39]=[C:38]([NH:40][C:41](=[O:53])[C:42]2[CH:43]=[CH:44][C:45]([O:48][C:49]([F:50])([F:51])[F:52])=[CH:46][CH:47]=2)[CH:37]=[CH:36][C:35]=1[C:54]1[CH:62]=[C:61]2[C:57]([CH2:58][N:59]([C@@H:64]([CH:69]([CH3:71])[CH3:70])[C:65]([OH:67])=[O:66])[C:60]2=[O:63])=[CH:56][CH:55]=1

Participants

3

Reactant 2

HCID 53303631(S)-2-(6-(4-Benzamidophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoic acidHCID 123185357HCID 123185357, compound

Product 1

HCID 67305920HCID 67305920, compoundYield 80%

Procedure

The compound of example 608 was prepared analogous to compound of example 98 by hydrolysis of compound of example 607.

Sources & evidence

ORD record
ord-7d22f52fb0a8482ea78ec6a28f3315c3
Source dataset
uspto-grants-2014_06
Patent number
US08748426B2

Reaction notes

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