HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 3-(4-(trifluoromethyl)phenyl)isoxazole-5-carboxylate → (S)-Methyl 3-methyl-2-(1-oxo-6-(4-(3-(4-(trifluoromethyl)phenyl)isoxazole-5-carboxamido)phenyl)isoindolin-2-yl)butanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 3-(4-(trifluoromethyl)phenyl)isoxazole-5-carboxylate | HCID 67282580 | — |
| Reactant | (S)-Methyl 3-methyl-2-(1-oxo-6-(4-(5-phenylthiazole-2-carboxamido)phenyl)isoindolin-2-yl)butanoate | HCID 123332092 | — |
| Reactant | (S)-Methyl 2-(6-(4-aminophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate | HCID 131731441 | — |
| Product | (S)-Methyl 3-methyl-2-(1-oxo-6-(4-(3-(4-(trifluoromethyl)phenyl)isoxazole-5-carboxamido)phenyl)isoindolin-2-yl)butanoate | HCID 123681234 | 62% |
Reaction Steps
The compound of example 619 was prepared analogous to the compound of example 611 by reaction of compound of example 6 with ethyl 3-(4-(trifluoromethyl)phenyl)isoxazole-5-carboxylate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08748426B2 |
| Source dataset | uspto-grants-2014_06 |
| ORD ID | ord-8086f1cac21e499db9b9c926688c9e6f |
| Source note | uspto-grants-2014_06 |