HRID404096

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)[C@@H](C(=O)O)N1Cc2ccc(-c3ccc(NC(=O)c4ccccc4)cc3)cc2C1=O

HCID53303631

未命名化合物

结构：COC(=O)[C@H](C(C)C)N1Cc2ccc(-c3ccc(NC(=O)c4cc(-c5ccc(C(F)(F)F)cc5)no4)cc3)cc2C1=O

HCID123681234

未命名化合物

PRODUCTS

生成物

结构：CC(C)[C@@H](C(=O)O)N1Cc2ccc(-c3ccc(NC(=O)c4cc(-c5ccc(C(F)(F)F)cc5)no4)cc3)cc2C1=O

HCID67307261

未命名化合物

收率 82%

PROCEDURE

实验过程

The compound of example 620 was prepared analogous to the compound of example 98 by hydrolysis of compound of example 619.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-e5bd04640f654a12a178fc4617d14685
来源数据集: uspto-grants-2014_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08748426B2
来源说明: uspto-grants-2014_06

反应 SMILES

C(NC1C=CC(C2C=C3C(CN([C@@H](C(C)C)C(O)=O)C3=O)=CC=2)=CC=1)(=O)C1C=CC=CC=1.[CH3:33][CH:34]([CH3:74])[C@H:35]([N:40]1[CH2:48][C:47]2[C:42](=[CH:43][C:44]([C:49]3[CH:54]=[CH:53][C:52]([NH:55][C:56]([C:58]4[O:62][N:61]=[C:60]([C:63]5[CH:68]=[CH:67][C:66]([C:69]([F:72])([F:71])[F:70])=[CH:65][CH:64]=5)[CH:59]=4)=[O:57])=[CH:51][CH:50]=3)=[CH:45][CH:46]=2)[C:41]1=[O:73])[C:36]([O:38]C)=[O:37]>>[CH3:33][CH:34]([CH3:74])[C@H:35]([N:40]1[CH2:48][C:47]2[C:42](=[CH:43][C:44]([C:49]3[CH:50]=[CH:51][C:52]([NH:55][C:56]([C:58]4[O:62][N:61]=[C:60]([C:63]5[CH:64]=[CH:65][C:66]([C:69]([F:72])([F:71])[F:70])=[CH:67][CH:68]=5)[CH:59]=4)=[O:57])=[CH:53][CH:54]=3)=[CH:45][CH:46]=2)[C:41]1=[O:73])[C:36]([OH:38])=[O:37]