HRID404097

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID1477779

methyl 4-(1,3-oxazol-5-yl)benzoate

C11H9NO3

结构：COC(=O)[C@H](C(C)C)N1Cc2ccc(-c3ccc(NC(=O)c4ncc(-c5ccccc5)s4)cc3)cc2C1=O

HCID123332092

未命名化合物

结构：COC(=O)[C@H](C(C)C)N1Cc2ccc(-c3ccc(N)cc3)cc2C1=O

HCID131731441

未命名化合物

PRODUCTS

生成物

结构：COC(=O)[C@H](C(C)C)N1Cc2ccc(-c3ccc(NC(=O)c4ccc(-c5cnco5)cc4)cc3)cc2C1=O

HCID131731590

未命名化合物

收率 58%

PROCEDURE

实验过程

The compound of example 621 was prepared analogous to the compound of example 611 by reaction of compound of example 6 with commercially available methyl 4-(oxazol-5-yl)benzoate (Ryan Scientific, USA).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-316bae5aa61047c18157922ec84ec979
来源数据集: uspto-grants-2014_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08748426B2
来源说明: uspto-grants-2014_06

反应 SMILES

[CH3:1][CH:2]([CH3:38])[C@H:3]([N:8]1[CH2:16][C:15]2[C:10](=[CH:11][C:12]([C:17]3[CH:22]=[CH:21][C:20]([NH:23][C:24](C4SC(C5C=CC=CC=5)=CN=4)=[O:25])=[CH:19][CH:18]=3)=[CH:13][CH:14]=2)[C:9]1=[O:37])[C:4]([O:6][CH3:7])=[O:5].NC1C=CC(C2C=C3C(CN([C@@H](C(C)C)C(OC)=O)C3=O)=CC=2)=CC=1.[O:64]1[C:68]([C:69]2[CH:78]=[CH:77][C:72](C(OC)=O)=[CH:71][CH:70]=2)=[CH:67][N:66]=[CH:65]1>>[CH3:38][CH:2]([CH3:1])[C@H:3]([N:8]1[CH2:16][C:15]2[C:10](=[CH:11][C:12]([C:17]3[CH:18]=[CH:19][C:20]([NH:23][C:24](=[O:25])[C:72]4[CH:71]=[CH:70][C:69]([C:68]5[O:64][CH:65]=[N:66][CH:67]=5)=[CH:78][CH:77]=4)=[CH:21][CH:22]=3)=[CH:13][CH:14]=2)[C:9]1=[O:37])[C:4]([O:6][CH3:7])=[O:5]