HCID 123332092, compound → HCID 178501451, compound

HRID 404101Notes

Reaction equation

HRID 404101 reaction equation
CC(C)[C@H](N1CC2C(=CC(C3C=CC(NC(C4SC(C5C=CC=CC=5)=CN=4)=O)=CC=3)=CC=2)C1=O)C(OC)=O.[NH2:39][C:40]1[CH:45]=[CH:44][C:43]([C:46]2[CH:54]=[C:53]3[C:49]([CH2:50][N:51]([C@@H:56]([CH:61]([CH3:63])[CH3:62])[C:57]([O:59][CH3:60])=[O:58])[C:52]3=[O:55])=[CH:48][CH:47]=2)=[CH:42][CH:41]=1.[C:64]1([C:70]2[NH:71][C:72]([C:75](OCC)=[O:76])=[N:73][N:74]=2)[CH:69]=[CH:68][CH:67]=[CH:66][CH:65]=1>>[CH3:62][CH:61]([CH3:63])[C@H:56]([N:51]1[CH2:50][C:49]2[C:53](=[CH:54][C:46]([C:43]3[CH:42]=[CH:41][C:40]([NH:39][C:75]([C:72]4[NH:71][C:70]([C:64]5[CH:65]=[CH:66][CH:67]=[CH:68][CH:69]=5)=[N:74][N:73]=4)=[O:76])=[CH:45][CH:44]=3)=[CH:47][CH:48]=2)[C:52]1=[O:55])[C:57]([O:59][CH3:60])=[O:58]

Participants

4

Reactant 3

HCID 123332092HCID 123332092, compoundHCID 131731441(S)-Methyl 2-(6-(4-aminophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoateHCID 178470460HCID 178470460, compound

Product 1

HCID 178501451HCID 178501451, compound

Procedure

The compound of example 628 was prepared analogous to the compound of example 611 by reaction of compound of example 6 with ethyl 5-phenyl-4H-1,2,4-triazole-3-carboxylate.

Sources & evidence

ORD record
ord-fe06cbe09e2b40fe8ab5184bb7323cd0
Source dataset
uspto-grants-2014_06
Patent number
US08748426B2

Reaction notes

Loading…