(S)-2-(6-(4-Benzamidophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoic acid → HCID 178448299, compound

HRID 404102Notes

Reaction equation

HRID 404102 reaction equation
[C:1]([NH:9][C:10]1[CH:15]=[CH:14][C:13]([C:16]2[CH:24]=[C:23]3[C:19]([CH2:20][N:21]([C@@H:26]([CH:30]([CH3:32])[CH3:31])[C:27]([OH:29])=[O:28])[C:22]3=[O:25])=[CH:18][CH:17]=2)=[CH:12][CH:11]=1)(=[O:8])C1C=CC=CC=1.[C:33]1([C:39]2[NH:40][C:41](C(OCC)=O)=[N:42][N:43]=2)[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1>>[CH3:31][CH:30]([CH3:32])[C@H:26]([N:21]1[CH2:20][C:19]2[C:23](=[CH:24][C:16]([C:13]3[CH:14]=[CH:15][C:10]([NH:9][C:1]([C:41]4[NH:40][C:39]([C:33]5[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=5)=[N:43][N:42]=4)=[O:8])=[CH:11][CH:12]=3)=[CH:17][CH:18]=2)[C:22]1=[O:25])[C:27]([OH:29])=[O:28]

Participants

3

Reactant 2

HCID 53303631(S)-2-(6-(4-Benzamidophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoic acidHCID 178470460HCID 178470460, compound

Product 1

HCID 178448299HCID 178448299, compoundYield 77%

Procedure

The compound of example 629 was prepared analogous to the compound of example 98 by hydrolysis of compound of example 628.

Sources & evidence

ORD record
ord-1b61c3089c7e4051b9ab5f06fb1cb052
Source dataset
uspto-grants-2014_06
Patent number
US08748426B2

Reaction notes

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