methyl 4-(2-cyanopropan-2-yl)benzoate → HCID 131731591, compound

HRID 404103Notes

Reaction equation

HRID 404103 reaction equation
[CH3:1][CH:2]([CH3:38])[C@H:3]([N:8]1[CH2:16][C:15]2[C:10](=[CH:11][C:12]([C:17]3[CH:22]=[CH:21][C:20]([NH:23][C:24](C4SC(C5C=CC=CC=5)=CN=4)=[O:25])=[CH:19][CH:18]=3)=[CH:13][CH:14]=2)[C:9]1=[O:37])[C:4]([O:6][CH3:7])=[O:5].NC1C=CC(C2C=C3C(CN([C@@H](C(C)C)C(OC)=O)C3=O)=CC=2)=CC=1.[C:64]([C:66]([C:69]1[CH:78]=[CH:77][C:72](C(OC)=O)=[CH:71][CH:70]=1)([CH3:68])[CH3:67])#[N:65]>>[C:64]([C:66]([C:69]1[CH:78]=[CH:77][C:72]([C:24]([NH:23][C:20]2[CH:19]=[CH:18][C:17]([C:12]3[CH:11]=[C:10]4[C:15]([CH2:16][N:8]([C@@H:3]([CH:2]([CH3:1])[CH3:38])[C:4]([O:6][CH3:7])=[O:5])[C:9]4=[O:37])=[CH:14][CH:13]=3)=[CH:22][CH:21]=2)=[O:25])=[CH:71][CH:70]=1)([CH3:68])[CH3:67])#[N:65]

Participants

4

Reactant 3

HCID 14698604methyl 4-(2-cyanopropan-2-yl)benzoateHCID 123332092HCID 123332092, compoundHCID 131731441(S)-Methyl 2-(6-(4-aminophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate

Product 1

HCID 131731591HCID 131731591, compoundYield 58%

Procedure

The compound of example 630B was prepared analogous to the compound of example 611 by reaction of compound of example 6 with compound of example 630A.

Sources & evidence

ORD record
ord-2489208ae1424ae1ad4af2eddc82e049
Source dataset
uspto-grants-2014_06
Patent number
US08748426B2

Reaction notes

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