HCID 87350000, compound → HCID 131731592, compound

HRID 404105Notes

Reaction equation

HRID 404105 reaction equation
[CH3:1][CH:2]([CH3:38])[C@H:3]([N:8]1[CH2:16][C:15]2[C:10](=[CH:11][C:12]([C:17]3[CH:22]=[CH:21][C:20]([NH:23][C:24](C4SC(C5C=CC=CC=5)=CN=4)=[O:25])=[CH:19][CH:18]=3)=[CH:13][CH:14]=2)[C:9]1=[O:37])[C:4]([O:6][CH3:7])=[O:5].NC1C=CC(C2C=C3C(CN([C@@H](C(C)C)C(OC)=O)C3=O)=CC=2)=CC=1.[C:64]([C:66]([C:71]1[CH:79]=[CH:78][C:74](C(Cl)=O)=[CH:73][CH:72]=1)([CH2:69][CH3:70])[CH2:67][CH3:68])#[N:65]>>[C:64]([C:66]([C:71]1[CH:72]=[CH:73][C:74]([C:24]([NH:23][C:20]2[CH:21]=[CH:22][C:17]([C:12]3[CH:11]=[C:10]4[C:15]([CH2:16][N:8]([C@@H:3]([CH:2]([CH3:38])[CH3:1])[C:4]([O:6][CH3:7])=[O:5])[C:9]4=[O:37])=[CH:14][CH:13]=3)=[CH:18][CH:19]=2)=[O:25])=[CH:78][CH:79]=1)([CH2:67][CH3:68])[CH2:69][CH3:70])#[N:65]

Participants

4

Reactant 3

HCID 87350000HCID 87350000, compoundHCID 123332092HCID 123332092, compoundHCID 131731441(S)-Methyl 2-(6-(4-aminophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate

Product 1

HCID 131731592HCID 131731592, compoundYield 49%

Procedure

The compound of example 632 was prepared analogous to the compound of example 611 by reaction of compound of example 6 with 4-(3-cyanopentan-3-yl)benzoyl chloride.

Sources & evidence

ORD record
ord-b91d331e28b24037b0ab1fb35b3b35e5
Source dataset
uspto-grants-2014_06
Patent number
US08748426B2

Reaction notes

Loading…