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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 404108Generated: October 29, 2026

Ethyl 5-phenylthiazole-2-carboxylate → (S)-Methyl 3-methyl-2-(1-oxo-6-(5-(5-phenylthiazole-2-carboxamido)pyridin-2-yl)isoindolin-2-yl)butanoate

https://huagongshe.com/reaction/404108

Reaction equation

Participants

RoleNameHCIDCharge
ReactantEthyl 5-phenylthiazole-2-carboxylateHCID 12830686—
Reactant(S)-Methyl 3-methyl-2-(1-oxo-6-(4-(5-phenylthiazole-2-carboxamido)phenyl)isoindolin-2-yl)butanoateHCID 123332092—
Reactant(S)-Methyl 2-(6-(5-aminopyridin-2-yl)-1-oxoisoindolin-2-yl)-3-methylbutanoateHCID 131731548—
Product(S)-Methyl 3-methyl-2-(1-oxo-6-(5-(5-phenylthiazole-2-carboxamido)pyridin-2-yl)isoindolin-2-yl)butanoateHCID 12367281339%

Reaction Steps

The compound of example 636 was prepared analogous to the compound of example 611 by reaction of compound of example 392 with ethyl 5-phenylthiazole-2-carboxylate.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08748426B2
Source datasetuspto-grants-2014_06
ORD IDord-30d9b7bba76746ab86a5d8f021b541d6
Source noteuspto-grants-2014_06