5-Methyl-2-phenyl-1,3-oxazole-4-carboxylic acid → (S)-Methyl 3-methyl-2-(6-(4-(5-methyl-2-phenyloxazole-4-carboxamido)phenyl)-1-oxoisoindolin-2-yl)butanoate

HRID 404110Notes

Reaction equation

HRID 404110 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:16]=[C:15]3[C:11]([CH2:12][N:13]([C@@H:18]([CH:23]([CH3:25])[CH3:24])[C:19]([O:21][CH3:22])=[O:20])[C:14]3=[O:17])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.[CH3:26][C:27]1[O:31][C:30]([C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=2)=[N:29][C:28]=1[C:38](O)=[O:39]>>[CH3:24][CH:23]([CH3:25])[C@H:18]([N:13]1[CH2:12][C:11]2[C:15](=[CH:16][C:8]([C:5]3[CH:4]=[CH:3][C:2]([NH:1][C:38]([C:28]4[N:29]=[C:30]([C:32]5[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=5)[O:31][C:27]=4[CH3:26])=[O:39])=[CH:7][CH:6]=3)=[CH:9][CH:10]=2)[C:14]1=[O:17])[C:19]([O:21][CH3:22])=[O:20]

Participants

3

Reactant 2

HCID 3185335-Methyl-2-phenyl-1,3-oxazole-4-carboxylic acidHCID 131731441(S)-Methyl 2-(6-(4-aminophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate

Product 1

HCID 123480077(S)-Methyl 3-methyl-2-(6-(4-(5-methyl-2-phenyloxazole-4-carboxamido)phenyl)-1-oxoisoindolin-2-yl)butanoateYield 43%

Procedure

The compound of example 642 was prepared analogous to the compound of example 640 by reaction of compound of example 6 with commercially available 5-methyl-2-phenyloxazole-4-carboxylic acid (Maybridge Chemical Company, Ltd., UK).

Sources & evidence

ORD record
ord-6028cf093f5346c48609ccff782257fd
Source dataset
uspto-grants-2014_06
Patent number
US08748426B2

Reaction notes

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