5-Butylpyridine-2-carbonyl chloride → HCID 123631525, compound

HRID 404112Notes

Reaction equation

HRID 404112 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:16]=[C:15]3[C:11]([CH2:12][N:13]([C@@H:18]([CH:23]([CH3:25])[CH3:24])[C:19]([O:21][CH3:22])=[O:20])[C:14]3=[O:17])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.[CH2:26]([C:30]1[CH:31]=[CH:32][C:33]([C:36](Cl)=[O:37])=[N:34][CH:35]=1)[CH2:27][CH2:28][CH3:29]>>[CH2:26]([C:30]1[CH:31]=[CH:32][C:33]([C:36]([NH:1][C:2]2[CH:3]=[CH:4][C:5]([C:8]3[CH:16]=[C:15]4[C:11]([CH2:12][N:13]([C@@H:18]([CH:23]([CH3:25])[CH3:24])[C:19]([O:21][CH3:22])=[O:20])[C:14]4=[O:17])=[CH:10][CH:9]=3)=[CH:6][CH:7]=2)=[O:37])=[N:34][CH:35]=1)[CH2:27][CH2:28][CH3:29]

Participants

3

Reactant 2

HCID 135312855-Butylpyridine-2-carbonyl chlorideHCID 131731441(S)-Methyl 2-(6-(4-aminophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate

Product 1

HCID 123631525HCID 123631525, compoundYield 60%

Procedure

The compound of example 648 was prepared analogous to the compound of example 640 by reaction of compound of example 6 with commercially available 5-butylpicolinoyl chloride (Sigma Chemical Company, USA).

Sources & evidence

ORD record
ord-6dd06850d0be444298050bea44dd7053
Source dataset
uspto-grants-2014_06
Patent number
US08748426B2

Reaction notes

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