(S)-2-(6-(4-Benzamidophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoic acid → HCID 67307617, compound

HRID 404113Notes

Reaction equation

HRID 404113 reaction equation
C(NC1C=CC(C2C=C3C(CN([C@@H](C(C)C)C(O)=O)C3=O)=CC=2)=CC=1)(=O)C1C=CC=CC=1.[CH2:33]([C:37]1[CH:38]=[CH:39][C:40]([C:43]([NH:45][C:46]2[CH:51]=[CH:50][C:49]([C:52]3[CH:60]=[C:59]4[C:55]([CH2:56][N:57]([C@@H:62]([CH:67]([CH3:69])[CH3:68])[C:63]([O:65]C)=[O:64])[C:58]4=[O:61])=[CH:54][CH:53]=3)=[CH:48][CH:47]=2)=[O:44])=[N:41][CH:42]=1)[CH2:34][CH2:35][CH3:36]>>[CH2:33]([C:37]1[CH:38]=[CH:39][C:40]([C:43]([NH:45][C:46]2[CH:47]=[CH:48][C:49]([C:52]3[CH:60]=[C:59]4[C:55]([CH2:56][N:57]([C@@H:62]([CH:67]([CH3:68])[CH3:69])[C:63]([OH:65])=[O:64])[C:58]4=[O:61])=[CH:54][CH:53]=3)=[CH:50][CH:51]=2)=[O:44])=[N:41][CH:42]=1)[CH2:34][CH2:35][CH3:36]

Participants

3

Reactant 2

HCID 53303631(S)-2-(6-(4-Benzamidophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoic acidHCID 123631525HCID 123631525, compound

Product 1

HCID 67307617HCID 67307617, compoundYield 80.6%

Procedure

The compound of example 649 was prepared analogous to the compound of example 98 by hydrolysis of compound of example 648.

Sources & evidence

ORD record
ord-0e232a69ba684a6da457d7b1cae69cb1
Source dataset
uspto-grants-2014_06
Patent number
US08748426B2

Reaction notes

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