Quinoline-3-carbonyl Chloride → HCID 123677880, compound

HRID 404114Notes

Reaction equation

HRID 404114 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:16]=[C:15]3[C:11]([CH2:12][N:13]([C@@H:18]([CH:23]([CH3:25])[CH3:24])[C:19]([O:21][CH3:22])=[O:20])[C:14]3=[O:17])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.[N:26]1[C:35]2[C:30](=[CH:31][CH:32]=[CH:33][CH:34]=2)[CH:29]=[C:28]([C:36](Cl)=[O:37])[CH:27]=1>>[CH3:24][CH:23]([CH3:25])[C@H:18]([N:13]1[CH2:12][C:11]2[C:15](=[CH:16][C:8]([C:5]3[CH:4]=[CH:3][C:2]([NH:1][C:36]([C:28]4[CH:27]=[N:26][C:35]5[C:30]([CH:29]=4)=[CH:31][CH:32]=[CH:33][CH:34]=5)=[O:37])=[CH:7][CH:6]=3)=[CH:9][CH:10]=2)[C:14]1=[O:17])[C:19]([O:21][CH3:22])=[O:20]

Participants

3

Reactant 2

HCID 11030631Quinoline-3-carbonyl ChlorideHCID 131731441(S)-Methyl 2-(6-(4-aminophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate

Product 1

HCID 123677880HCID 123677880, compoundYield 20%

Procedure

The compound of example 650 was prepared analogous to the compound of example 640 by reaction of compound of example 6 with commercially available quinoline-3-carbonyl chloride.

Sources & evidence

ORD record
ord-fe366c8551454edc8104ce40007c9e63
Source dataset
uspto-grants-2014_06
Patent number
US08748426B2

Reaction notes

Loading…