HCID 87350048, compound → HCID 131731593, compound

HRID 404115Notes

Reaction equation

HRID 404115 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:16]=[C:15]3[C:11]([CH2:12][N:13]([C@@H:18]([CH:23]([CH3:25])[CH3:24])[C:19]([O:21][CH3:22])=[O:20])[C:14]3=[O:17])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.[N:26]1[CH:31]=[C:30]([C:32]2[CH:40]=[CH:39][C:35]([C:36](Cl)=[O:37])=[CH:34][CH:33]=2)[CH:29]=[N:28][CH:27]=1>>[CH3:24][CH:23]([CH3:25])[C@H:18]([N:13]1[CH2:12][C:11]2[C:15](=[CH:16][C:8]([C:5]3[CH:4]=[CH:3][C:2]([NH:1][C:36](=[O:37])[C:35]4[CH:34]=[CH:33][C:32]([C:30]5[CH:29]=[N:28][CH:27]=[N:26][CH:31]=5)=[CH:40][CH:39]=4)=[CH:7][CH:6]=3)=[CH:9][CH:10]=2)[C:14]1=[O:17])[C:19]([O:21][CH3:22])=[O:20]

Participants

3

Reactant 2

HCID 87350048HCID 87350048, compoundHCID 131731441(S)-Methyl 2-(6-(4-aminophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate

Product 1

HCID 131731593HCID 131731593, compoundYield 37%

Procedure

The compound of example 652 was prepared analogous to the compound of example 640 by reaction of compound of example 6 with commercially available 4-(pyrimidin-5-yl)benzoyl chloride.

Sources & evidence

ORD record
ord-1895120c979f4cd6a586979930e07a08
Source dataset
uspto-grants-2014_06
Patent number
US08748426B2

Reaction notes

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