(S)-2-(6-(4-Benzamidophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoic acid → HCID 67306211, compound

HRID 404116Notes

Reaction equation

HRID 404116 reaction equation
C(NC1C=CC(C2C=C3C(CN([C@@H](C(C)C)C(O)=O)C3=O)=CC=2)=CC=1)(=O)C1C=CC=CC=1.[CH3:33][CH:34]([CH3:71])[C@H:35]([N:40]1[CH2:48][C:47]2[C:42](=[CH:43][C:44]([C:49]3[CH:54]=[CH:53][C:52]([NH:55][C:56](=[O:69])[C:57]4[CH:62]=[CH:61][C:60]([C:63]5[CH:64]=[N:65][CH:66]=[N:67][CH:68]=5)=[CH:59][CH:58]=4)=[CH:51][CH:50]=3)=[CH:45][CH:46]=2)[C:41]1=[O:70])[C:36]([O:38]C)=[O:37]>>[CH3:33][CH:34]([CH3:71])[C@H:35]([N:40]1[CH2:48][C:47]2[C:42](=[CH:43][C:44]([C:49]3[CH:50]=[CH:51][C:52]([NH:55][C:56](=[O:69])[C:57]4[CH:62]=[CH:61][C:60]([C:63]5[CH:68]=[N:67][CH:66]=[N:65][CH:64]=5)=[CH:59][CH:58]=4)=[CH:53][CH:54]=3)=[CH:45][CH:46]=2)[C:41]1=[O:70])[C:36]([OH:38])=[O:37]

Participants

3

Reactant 2

HCID 53303631(S)-2-(6-(4-Benzamidophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoic acidHCID 131731593HCID 131731593, compound

Product 1

HCID 67306211HCID 67306211, compoundYield 97%

Procedure

The compound of example 653 was prepared analogous to the compound of example 98 by hydrolysis of compound of example 652.

Sources & evidence

ORD record
ord-272bef5378e34e3ab9fc9610f4f06b81
Source dataset
uspto-grants-2014_06
Patent number
US08748426B2

Reaction notes

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