4-Pentylbenzoyl chloride → HCID 67307615, compound

HRID 404129Notes

Reaction equation

HRID 404129 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]3[C:14](=[CH:15][CH:16]=2)[CH2:13][N:12]([CH:17]([CH:22]([CH3:24])[CH3:23])[C:18]([O:20][CH3:21])=[O:19])[CH2:11]3)=[CH:4][CH:3]=1.[CH2:25]([C:30]1[CH:38]=[CH:37][C:33]([C:34](Cl)=[O:35])=[CH:32][CH:31]=1)[CH2:26][CH2:27][CH2:28][CH3:29]>>[CH3:23][CH:22]([CH3:24])[CH:17]([N:12]1[CH2:11][C:10]2[C:14](=[CH:15][CH:16]=[C:8]([C:5]3[CH:4]=[CH:3][C:2]([NH:1][C:34](=[O:35])[C:33]4[CH:37]=[CH:38][C:30]([CH2:25][CH2:26][CH2:27][CH2:28][CH3:29])=[CH:31][CH:32]=4)=[CH:7][CH:6]=3)[CH:9]=2)[CH2:13]1)[C:18]([O:20][CH3:21])=[O:19]

Participants

3

Reactant 2

HCID 1708124-Pentylbenzoyl chlorideHCID 67306308Methyl 2-(5-(4-aminophenyl)isoindolin-2-yl)-3-methylbutanoate

Product 1

HCID 67307615HCID 67307615, compoundYield 22%

Procedure

The compound of example 675 was prepared analogous to the compound of example 663 by reaction of compound of example 673 with 4-(n-pentyl)benzoyl chloride.

Sources & evidence

ORD record
ord-bd16cb547c7244778f63cae4be66ece8
Source dataset
uspto-grants-2014_06
Patent number
US08748426B2

Reaction notes

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