2-(Trifluoromethyl)phenyl isocyanate → HCID 67307658, compound

HRID 404130Notes

Reaction equation

HRID 404130 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]3[C:14](=[CH:15][CH:16]=2)[CH2:13][N:12]([CH:17]([CH:22]([CH3:24])[CH3:23])[C:18]([O:20][CH3:21])=[O:19])[CH2:11]3)=[CH:4][CH:3]=1.[F:25][C:26]([F:37])([F:36])[C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=1[N:33]=[C:34]=[O:35]>>[CH3:23][CH:22]([CH3:24])[CH:17]([N:12]1[CH2:11][C:10]2[C:14](=[CH:15][CH:16]=[C:8]([C:5]3[CH:4]=[CH:3][C:2]([NH:1][C:34]([NH:33][C:28]4[CH:29]=[CH:30][CH:31]=[CH:32][C:27]=4[C:26]([F:25])([F:36])[F:37])=[O:35])=[CH:7][CH:6]=3)[CH:9]=2)[CH2:13]1)[C:18]([O:20][CH3:21])=[O:19]

Participants

3

Reactant 2

HCID 167942-(Trifluoromethyl)phenyl isocyanateHCID 67306308Methyl 2-(5-(4-aminophenyl)isoindolin-2-yl)-3-methylbutanoate

Product 1

HCID 67307658HCID 67307658, compoundYield 34%

Procedure

The compound of example 678 was prepared analogous to the compound of example 7 by reaction of compound of example 673 with 2-trifluoromethyl phenyl isocyanate.

Sources & evidence

ORD record
ord-61d37b368e274f18a51ceeea5088c486
Source dataset
uspto-grants-2014_06
Patent number
US08748426B2

Reaction notes

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