2-Bromo-5-methoxypyridine → 2-(2,4-Difluorophenyl)-1,1-difluoro-1-(5-methoxypyridin-2-yl)-3-(1H-tetrazol-1-yl)propan-2-ol

Participants

Role	Name	HCID	Charge
Reactant	2-Bromo-5-methoxypyridine	HCID 11148151	—
Reactant	1-(5-(4-Chloro-2-fluorobenzyloxy)pyridin-2-yl)-2-(2,4-difluorophenyl)-1,1-difluoro-3-(1H-tetrazol-1-yl)propan-2-ol	HCID 71475670	—
Product	2-(2,4-Difluorophenyl)-1,1-difluoro-1-(5-methoxypyridin-2-yl)-3-(1H-tetrazol-1-yl)propan-2-ol	HCID 71138496	—

Reaction Steps

Compound 8 was prepared in a similar manner to compound 1 from 2-bromo-5-methoxypyridine to afford a tan solid (28 mg, 10%). 1H NMR (500 MHz, CDCl3): δ 8.74 (s, 1H), 8.19 (s, 1H), 7.63 (br s, 1H), 7.51 (d, J=8.5 Hz, 1H), 7.34-7.33 (m, 1H), 7.24-7.23 (m, 1H), 6.75-6.74 (m, 1H), 6.67-6.66 (m, 1H), 5.58 (d, J=14.0 Hz, 1H), 5.07 (d, J=14.0 Hz, 1H), 3.88 (s, 3H). MS (ESI): m/z 382 [M+−1]. HPLC: 92.37%.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08748461B2
Source dataset	uspto-grants-2014_06
ORD ID	ord-d5c26648651445e788af1a66774d4148
Source note	uspto-grants-2014_06