HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,4-Benzenediamine, N1,N1-dimethyl-, hydrochloride (1:2) → 1-(4-(Dimethylamino)phenyl)-3-(7-(hydroxyamino)-7-oxoheptyl)urea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,4-Benzenediamine, N1,N1-dimethyl-, hydrochloride (1:2) | HCID 2724166 | — |
| Reactant | 4-(aminomethyl)-N,N-dimethylaniline dihydrochloride | HCID 2734633 | — |
| Reactant | 7-Amino-heptanoic acid benzyl ester toluene-4-sulfonic acid | HCID 18439219 | — |
| Reactant | 4-[3-(4-Dimethylamino-benzyl)-ureido]-N-hydroxy-butyramide | HCID 57598161 | — |
| Product | 1-(4-(Dimethylamino)phenyl)-3-(7-(hydroxyamino)-7-oxoheptyl)urea | HCID 11558827 | — |
Reaction Steps
Compound 7 was prepared using the methodology described for the preparation of compound 2, by substituting 4-amino-butyric acid benzyl ester toluene-4-sulfonic acid with 7-amino-heptanoic acid benzyl ester toluene-4-sulfonic acid and 4-dimethylaminobenzylamine dihydrochloride with N,N-dimethyl-benzene-1,4-diamine dihydrochloride. 1H NMR (300 MHz, DMSO-d6) δ (ppm) 10.34 (br, s, 1H), 8.64 (br s, 1H), 7.98 (br s, 1H), 7.17 (d, J=9.0 Hz, 2H), 6.65 (d, J=9.0 Hz, 2H), 5.91 (t, J=5.7 Hz, 1H), 3.03 (dt, J=6.6, 6.0 Hz, 2H), 2.79 (s, 6H), 1.94 (t, J=7.5 Hz, 2H), 1.48 (m, 2H), 1.39 (m, 2H), 1.25 (m, 4H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08748463B2 |
| Source dataset | uspto-grants-2014_06 |
| ORD ID | ord-b7806a12c34647fc95ef38b0c5f4b7f1 |
| Source note | uspto-grants-2014_06 |