HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phenylethanolamine → N-hydroxy-4-[3-(2-hydroxy-2-phenyl-ethyl)-ureido]-butyramide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phenylethanolamine | HCID 1000 | — |
| Reactant | 4-[3-(4-Dimethylamino-benzyl)-ureido]-N-hydroxy-butyramide | HCID 57598161 | — |
| Product | N-hydroxy-4-[3-(2-hydroxy-2-phenyl-ethyl)-ureido]-butyramide | HCID 57598156 | — |
Reaction Steps
Compound 15 was prepared using the methodology described for the preparation of compound 2, by substituting 4-dimethylaminobenzylamine dihydrochloride with 2-amino-1-phenyl-ethanol. 1H NMR (CD3OD) δ 7.42-7.24 (m, 5H), 4.73 (dd, J=7.8, 4.2 Hz, 1H), 3.43 (dd, J=13.8, 4.2 Hz, 1H), 3.26 (dd, J=13.8, 7.8 Hz, 1H), 3.14 (t, J=6.9 Hz, 2H), 2.12 (t, J=7.2 Hz, 2H), 1.76 (m, 2H). 13C NMR (CD3OD) δ 172.7, 161.5, 144.2, 129.5, 128.7, 127.3, 74.6, 48.1, 39.4, 30.6, 27.0.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08748463B2 |
| Source dataset | uspto-grants-2014_06 |
| ORD ID | ord-e5a29dcb09194994b48f98b57c9f1a43 |
| Source note | uspto-grants-2014_06 |