Triethylamine → HCID 67952054, compound

Participants

Reaction Steps

To a solution of the type A crystal of (2S)-2-amino-3-(3,4-bis((2-(benzoyloxy)-2-methylpropanoyl)oxy)phenyl)propanoic acid tosylate produced in Example 6 or the type B crystal of (2S)-2-amino-3-(3,4-bis((2-(benzoyloxy)-2-methylpropanoyl)oxy)phenyl)propanoic acid tosylate produced in Example 7 (167 g) in acetonitrile (2080 mL) and water (42 mL), a solution of triethylamine (21.4 g) in acetonitrile (420 mL) was added dropwise. After the reaction mixture was stirred for 16 hours, a deposited solid was obtained by filtration and washed with acetonitrile (500 mL). Then, the solid was dried at 50° C. for 16 hours, whereby a crude product of the title compound (106 g, 81%) was obtained as a white solid.

Provenance & Evidence