HCID 58380065, compound → HCID 57467667, compound

Participants

Reaction Conditions

Reaction Steps

Compound H6.4 (2.50 g, 8.41 mmol) was dissolved in 27 mL DMSO and 3 mL water. The resulting mixture was heated to 150° C. and stirred for 30 minutes. After the reaction was complete, the reaction was diluted with 120 mL water and extracted twice with 50 mL EtOAc. The combined organic layers were washed with brine, dried over MgSO4, and concentrated onto silica gel. The resulting product was purified by column chromatography with 10% EtOAc/hexane to afford desired product H6.5 (1.76 g, 87.5%). MS ESI (pos.) m/e: 240.1 (M+H)+.

Provenance & Evidence