反应详情

To a flask with methyl 3-(cyclopropyl(hydroxy)methyl)-4-hydroxybenzoate (T29.2) (845 mg, 0.38 mmol) was added manganese (IV) oxide (1.65 g, 1.9 mmol). Then dioxane 3.5 mL was added and the reaction was heated at reflux for 4 hours. The reaction was filtered and concentrated and silica gel chromatography afforded 693 mg of T29.3 (83%).

1. temperaturethe reaction was heated
2. temperatureat reflux for 4 hours
3. filtrationThe reaction was filtered
4. concentrationconcentrated
5. customsilica gel chromatography afforded 693 mg of T29.3 (83%)