HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzenesulfonic acid, 4-methyl-, compd. with pyridine (1:1) → [2'-Fluoro-5'-methoxy-2-(1-methoxy-cyclopentyl)-biphenyl-4-yl]-methanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzenesulfonic acid, 4-methyl-, compd. with pyridine (1:1) | HCID 466102 | — |
| Reactant | tert-Butyl-[2'-fluoro-5'-methoxy-2-(1-methoxy-cyclopentyl)-biphenyl-4-ylmethoxy]-dimethyl-silane | HCID 57706027 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | [2'-Fluoro-5'-methoxy-2-(1-methoxy-cyclopentyl)-biphenyl-4-yl]-methanol | HCID 57706279 | 61% |
Reaction Steps
To a solution of 20.5 (66 mg, 168 μmol) in MeOH (3 mL), was added PPTS (11 mg, 45 μmol). The resulting mixture was stirred overnight. Solvent was removed in vacuo to give a residue which was purified by CombiFlash® chromatography to give an oil (30 mg, 61%). MS ESI m/e: 331.2 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08748462B2 |
| Source dataset | uspto-grants-2014_06 |
| ORD ID | ord-5f98bddfc4e44f00a8962a1dcc1f00c4 |
| Source note | uspto-grants-2014_06 |