反应详情

To a solution of 20.6 (30 mg, 91 mmol) in 1 mL of DCM at 0° C., was added TEA (11 mg, 109 μmol) followed by methanesulfonyl chloride (12 mg, 109 mmol). The mixture was stirred at room temperature for 30 minutes. The reaction was then quenched with water and extracted with EtOAc. The organic layers were combined, washed with water and brine and then dried over anhydrous sodium sulfate. After filtration, the organic solvent was removed in vacuo to give the product as a residue which was used without further purification. MS ESI m/e: 409.1 (M+H)+.

1. customThe reaction was then quenched with water
2. extractionextracted with EtOAc
3. washwashed with water and brine
4. dry with materialdried over anhydrous sodium sulfate
5. filtrationAfter filtration
6. customthe organic solvent was removed in vacuo
7. customto give the product as a residue which
8. customwas used without further purification