HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 404391Generated: October 26, 2026
Diethyl Ether → (4-(5-Fluoro-2-methoxypyridin-4-yl)-3-(1-vinylcyclopentyl)phenyl)methanol
https://huagongshe.com/reaction/404391
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | Aluminium lithium hydride | HCID 21226445 | — |
| Reactant | Methyl 4-(5-fluoro-2-methoxypyridin-4-yl)-3-(1-vinylcyclopentyl)benzoate | HCID 57467655 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | (4-(5-Fluoro-2-methoxypyridin-4-yl)-3-(1-vinylcyclopentyl)phenyl)methanol | HCID 57706064 | — |
Reaction Steps
To a solution of methyl 4-(5-fluoro-2-methoxypyridin-4-yl)-3-(1-vinylcyclopentyl)benzoate 26.5 (51.0 mg, 143 μmol) in THF (2.0 mL) was slowly added LAH, (1.0 M solution in diethyl ether (0.30 mL, 287 μmol)) at room temperature. The resulting mixture was stirred at 50° C. for 1 hour. The product was obtained after work up and solvent removal. The desired product was used in the next step without further purification. MS ESI (pos.) m/e: 328.2 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08748462B2 |
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| Source dataset | uspto-grants-2014_06 |
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| ORD ID | ord-a0e83c3fd8ea414a82f8e274cc8403f7 |
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| Source note | uspto-grants-2014_06 |
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