Lithium Hydroxide → HCID 58380396, compound

Participants

Reaction Steps

The reaction mixture of compound 123.1 (48.4 mg, 94 μmol) and lithium hydroxide (0.25 mL 3.3 M LiOH(aq), 0.75 mmol) in MeOH (0.6 m 1) was stirred at room temperature for 3 hours. The resulting mixture was purified by preparative HPLC (reverse phase) to give Example 123 (30.0 mg, 66% yield over two steps). MS ESI (pos.) M/E: 488.2 (M+H). 1H-NMR (500 MHz, CDCl3) δ ppm 7.94 (1H, s), 7.58 (1H, s), 7.33 (1H, d, J=7.8 Hz), 7.15 (1H, d, J=8.1 Hz), 7.00 (1H, d, J=7.8 Hz), 6.85 (1H, dd, J=8.3, 2.4 Hz), 6.62 (1H, d, J=4.9 Hz), 6.36 (1H, d, J=2.2 Hz), 5.96 (1H, dd, J=17.5, 10.6 Hz), 5.05 (2H, s), 4.71-4.86 (2H, m), 3.88 (3H, s), 2.93-3.05 (2H, m), 2.39 (1H, dd, J=8.3, 6.2 Hz), 2.32 (1H, dd, J=8.3, 6.2 Hz), 1.96-2.06 (1H, m), 1.70 (1H, t, J=5.4 Hz), 1.51 (1H, dd, J=8.3, 4.8 Hz), 1.27 (3H, s), 1.25 (3H, s).

Provenance & Evidence