3-Isocyanatopyridine → N-[4-(4,6-Di-4-morpholinyl-1,3,5-triazin-2-yl)phenyl]-N′-3-pyridinylurea

HRID 404406Notes

Reaction equation

HRID 404406 reaction equation
[N:1]1([C:7]2[N:12]=[C:11]([N:13]3[CH2:18][CH2:17][O:16][CH2:15][CH2:14]3)[N:10]=[C:9]([C:19]3[CH:25]=[CH:24][C:22]([NH2:23])=[CH:21][CH:20]=3)[N:8]=2)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[N:26]1[CH:31]=[CH:30][CH:29]=[C:28]([N:32]=[C:33]=[O:34])[CH:27]=1>>[N:1]1([C:7]2[N:12]=[C:11]([N:13]3[CH2:18][CH2:17][O:16][CH2:15][CH2:14]3)[N:10]=[C:9]([C:19]3[CH:25]=[CH:24][C:22]([NH:23][C:33]([NH:32][C:28]4[CH:27]=[N:26][CH:31]=[CH:30][CH:29]=4)=[O:34])=[CH:21][CH:20]=3)[N:8]=2)[CH2:2][CH2:3][O:4][CH2:5][CH2:6]1

Participants

3

Reactant 2

HCID 27604933-IsocyanatopyridineHCID 453790874-(4,6-Dimorpholino-1,3,5-triazin-2-yl)aniline

Product 1

HCID 44513885N-[4-(4,6-Di-4-morpholinyl-1,3,5-triazin-2-yl)phenyl]-N′-3-pyridinylurea

Procedure

Starting from 4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)aniline (0.08 g 0.23 mmoles) and 3-pyridyl isocyanate (30 mg, 0.25 mmoles) the title compound was isolated as a white solid. The product was purified by Silica gel column chromatography by eluting it with 10% MeOH: ethyl acetate. Yield; 60 mg (56%); (M+H)=463.5.

Sources & evidence

ORD record
ord-445f1f86aa164e6da58f2461f77c3c04
Source dataset
uspto-grants-2014_06
Patent number
US08748421B2

Reaction notes

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