4-Aminobenzamide → 4-[({4-[4-Morpholin-4-yl-6-(3-oxa-8-azabicyclo[3.2.1]oct-8-yl)-1,3,5-triazin-2-yl]phenyl}carbamoyl)amino]benzamide

Participants

Role	Name	HCID	Charge
Reactant	4-Aminobenzamide	HCID 76079	—
Reactant	Triphosgene	HCID 94429	—
Reactant	4-[4-Morpholin-4-yl-6-(3-oxa-8-azabicyclo[3.2.1]oct-8-yl)-1,3,5-triazin-2-yl]aniline	HCID 67021644	—
Product	4-[({4-[4-Morpholin-4-yl-6-(3-oxa-8-azabicyclo[3.2.1]oct-8-yl)-1,3,5-triazin-2-yl]phenyl}carbamoyl)amino]benzamide	HCID 67021876	33.3%

Reaction Steps

Following the procedure described in example 34, reaction of 4-[4-morpholin-4-yl-6-(3-oxa-8-azabicyclo[3.2.1]oct-8-yl)-1,3,5-triazin-2-yl]aniline (22 mg, 0.06 mmol) (22 mg, 0.06 mmol, triphosgene (18 mg, 0.06 mmol) and 4-aminobenzamide (25 mg, 0.18 mmol) gave the title compound as off-white solid (10.6 mg, 33% yield). MS (ESI) m/z 531.2.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08748421B2
Source dataset	uspto-grants-2014_06
ORD ID	ord-0eb1849f84a64551859e5d706846a66c
Source note	uspto-grants-2014_06