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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 404442Generated: October 30, 2026

Hydrochloric Acid → 1-(4-(4,6-Dimorpholino-1,3,5-triazin-2-yl)phenyl)-3-(4-(4-methylpiperazine-1-carbonyl)phenyl)urea hydrochloride

https://huagongshe.com/reaction/404442

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydrochloric AcidHCID 313—
ReactantMethanolHCID 887—
ReactantHCID 44516309HCID 44516309—
Solvent1,4-DioxaneHCID 31275—
Product1-(4-(4,6-Dimorpholino-1,3,5-triazin-2-yl)phenyl)-3-(4-(4-methylpiperazine-1-carbonyl)phenyl)urea hydrochlorideHCID 45379224100%

Reaction Steps

To a 1-(4-(4,6-dimorpholino-1,3,5-triazin-2-yl)phenyl)-3-(4-(4-methylpiperazine-1-carbonyl)phenyl)urea (70 mg, 0.119 mmol) and MeOH (1 mL) was added 4N HCl in Dioxane (1 mL), stirred for 3 hrs. The solid was filtered and washed with ether to give the product as a white solid (74 mg, yield=100%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08748421B2
Source datasetuspto-grants-2014_06
ORD IDord-ab165fdf647944b2942d9e96be8564a4
Source noteuspto-grants-2014_06