HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Tetramethyl-1,3,2-dioxaborolan-2-yl)aniline → 1-(4-(4-(4-Aminophenyl)-6-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-1,3,5-triazin-2-yl)phenyl)-3-methylurea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Tetramethyl-1,3,2-dioxaborolan-2-yl)aniline | HCID 2734620 | — |
| Reactant | 1-(4-(4-(8-Oxa-3-azabicyclo[3.2.1]octan-3-yl)-6-chloro-1,3,5-triazin-2-yl)phenyl)-3-methylurea | HCID 86636526 | — |
| Product | 1-(4-(4-(4-Aminophenyl)-6-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-1,3,5-triazin-2-yl)phenyl)-3-methylurea | HCID 67437223 | 49% |
Reaction Steps
The title compound was prepared by following the procedure of example 462 step 4 using 1-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-6-chloro-1,3,5-triazin-2-yl)phenyl)-3-methylurea and 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline. Yield 2.8 g, 49% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08748421B2 |
| Source dataset | uspto-grants-2014_06 |
| ORD ID | ord-eac5adc270bb45f2b1587d8ec838ece9 |
| Source note | uspto-grants-2014_06 |