HuagongsheHuagongshe Chemistry Print Report · For research reference only
phenyl N-(3-carbamoylphenyl)carbamate → 3-[({4-[4-{4-[(Methylcarbamoyl)amino]phenyl}-6-(8-oxa-3-azabicyclo[3.2.1]oct-3-yl)-1,3,5-triazin-2-yl]phenyl}carbamoyl)amino]benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | phenyl N-(3-carbamoylphenyl)carbamate | HCID 60630270 | — |
| Reactant | 1-(4-(4-(4-Aminophenyl)-6-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-1,3,5-triazin-2-yl)phenyl)-3-methylurea | HCID 67437223 | — |
| Product | 3-[({4-[4-{4-[(Methylcarbamoyl)amino]phenyl}-6-(8-oxa-3-azabicyclo[3.2.1]oct-3-yl)-1,3,5-triazin-2-yl]phenyl}carbamoyl)amino]benzamide | HCID 67021910 | 13% |
Reaction Steps
The title compound was prepared by following the procedure of example 462 step 7 using 1-(4-(4-(4-aminophenyl)-6-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-1,3,5-triazin-2-yl)phenyl)-3-methylurea and phenyl 3-carbamoylphenylcarbamate. Yield 90 mg, 13% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08748421B2 |
| Source dataset | uspto-grants-2014_06 |
| ORD ID | ord-3aa35cf2d19243be9bc18320103e8344 |
| Source note | uspto-grants-2014_06 |