Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 404513생성일: 2026년 10월 25일
Ethylenethiourea → N-[4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl]-4,5-dihydro-1H-imidazol-2-amine
https://huagongshe.com/reaction/404513
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Ethylenethiourea | HCID 2723650 | — |
| 반응물 | 4-(4,6-Dimorpholino-1,3,5-triazin-2-yl)aniline | HCID 45379087 | — |
| 촉매 | Mercuric Chloride | HCID 24085 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | N-[4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl]-4,5-dihydro-1H-imidazol-2-amine | HCID 67439160 | 22% |
반응 단계
A mixture of 4-(4,6-dimorpholino-1,3,5-triazin-2-yl)aniline (40 mg, 0.12 mmol), imidazolidine-2-thione (15 mg, 0.15 mmol) and mercury(II) chloride (40 mg, 0.15 mmol) in 2 mL of DMF was stirred at 140° C. 16 hr. Then the reaction mixture was cooled to room temperature and filtered through Celite™. The filtration was concentrated and purified by reverse phase chromatography to give N-[4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl]-4,5-dihydro-1H-imidazol-2-amine (9.0 mg, 22% yield). HPLC: Rt=1.74 min; MS 411 [M+H].
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08748421B2 |
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| 출처 데이터셋 | uspto-grants-2014_06 |
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| ORD ID | ord-1ab558f1b3484cb1968be80fff4ed51f |
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| 출처 메모 | uspto-grants-2014_06 |
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