HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloro-3-(trifluoromethyl)pyridine → 3-Methyl-1-[3-(trifluoromethyl)pyridin-2-yl]piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloro-3-(trifluoromethyl)pyridine | HCID 589833 | — |
| Reactant | 2-Methylpiperazine, (R)- | HCID 7330434 | — |
| Reactant | 3-(Trimethylsilyl)aniline | HCID 12488883 | — |
| Product | 3-Methyl-1-[3-(trifluoromethyl)pyridin-2-yl]piperazine | HCID 11288036 | 92.6% |
Reaction Steps
Compound A-03 can be synthesized according to method 1. Just of Scheme 1, R1 is —CF3; R2 is -Me; R3 is p-SiMe3. More specifically, compound 1 is 2-chloro-3-(trifluoromethyl)-pyridine (2 g); compound 2 is (R)-2-methylpiperazine; the synthesized compound 3 is 3-methyl-1-(3-trifluoromethyl-2-pyridyl)piperazine (2.5 g, yield about 92.6%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08748610B2 |
| Source dataset | uspto-grants-2014_06 |
| ORD ID | ord-8a7044d1d7f24205b4d14a222192fb8b |
| Source note | uspto-grants-2014_06 |