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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 404556Generated: October 26, 2026

2-Chloro-3-(trifluoromethyl)pyridine → 3-Methyl-1-[3-(trifluoromethyl)pyridin-2-yl]piperazine

https://huagongshe.com/reaction/404556

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Chloro-3-(trifluoromethyl)pyridineHCID 589833—
Reactant2-Methylpiperazine, (R)-HCID 7330434—
Reactant3-(Trimethylsilyl)anilineHCID 12488883—
Product3-Methyl-1-[3-(trifluoromethyl)pyridin-2-yl]piperazineHCID 1128803692.6%

Reaction Steps

More specifically, compound 1 is 2-chloro-3-trifluoromethylpyridine (2 g); compound 2 is (R)-2-methyl piperazine; the synthesized compound 3 is 3-methyl-1-(3-trifluoromethyl-2-pyridyl)piperazine (2.5 g, yield about 92.6%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08748610B2
Source datasetuspto-grants-2014_06
ORD IDord-8b4c94d80efa40da82e1d42f1560c2f8
Source noteuspto-grants-2014_06