2,3-Dichloropyridine → 1-(3-Chloropyridin-2-yl)-3-methylpiperazine

HRID 404557Notes

Reaction equation

HRID 404557 reaction equation
C[Si](C)(C)C1C=C(C=CC=1)N.Cl[C:13]1[C:18]([Cl:19])=[CH:17][CH:16]=[CH:15][N:14]=1.[CH3:20][C@@H:21]1[CH2:26][NH:25][CH2:24][CH2:23][NH:22]1>>[CH3:20][CH:21]1[NH:22][CH2:23][CH2:24][N:25]([C:13]2[C:18]([Cl:19])=[CH:17][CH:16]=[CH:15][N:14]=2)[CH2:26]1

Participants

4

Reactant 3

HCID 169882,3-DichloropyridineHCID 73304342-Methylpiperazine, (R)-HCID 124888833-(Trimethylsilyl)aniline

Product 1

HCID 227275611-(3-Chloropyridin-2-yl)-3-methylpiperazineYield 93.2%

Procedure

Compound A-10 can be synthesized according to method 1. Just of Scheme 1, R1 is —Cl; R2 is -Me; R3 is m-SiMe3. More specifically, compound 1 is 2,3-dichloro pyridine (6 g); compound 2 is (R)-2-methyl piperazine; the synthesized compound 3 is 3-methyl-1-(3-chloro-2-pyridyl)piperazine (8 g, yield about 93.2%).

Workup

  1. customCompound A-10 can be synthesized

Sources & evidence

ORD record
ord-0522742437e24775abbfde8d0b3added
Source dataset
uspto-grants-2014_06
Patent number
US08748610B2

Reaction notes

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