HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 1-(3-chloropyridin-2-yl)-1,2,3,6-tetrahydropyridine-4-carbonyl Chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 1-(3-chloropyridin-2-yl)-1,2,3,6-tetrahydropyridine-4-carboxylic Acid | HCID 21904727 | — |
| Solvent | Benzene | HCID 241 | — |
| Product | 1-(3-chloropyridin-2-yl)-1,2,3,6-tetrahydropyridine-4-carbonyl Chloride | HCID 58319493 | — |
Reaction Steps
A solution of 1-(3-chloropyridin-2-yl)-1,2,3,6-tetrahydropyridine-4-carboxylic acid (compound 24) (8 g, 34 mmol) and thionyl chloride (12 g, 100 mmol) in benzene was refluxed for two hours. The solvent was evaporated to give a crude product, which can be directly used for the next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08748610B2 |
| Source dataset | uspto-grants-2014_06 |
| ORD ID | ord-ab5dc4d76c10477c9dc61edd2c8a007b |
| Source note | uspto-grants-2014_06 |