Trifluoroacetic acid → HCID 68109011, compound

Participants

Reaction Steps

At 0° C., 5 ml TFA was slowly added into a solution of tert-butyl 3-((dimethylamino)methyl)-4-(trimethylsilyl)phenylcarbamate (compound 29) in CH2Cl2. The reaction mixture was stirred at 0° for 2 hours. After adjusted with saturated NaHCO3 solution to pH 8, the reaction mixture was extracted by ethyl acetate. The organic layer was dried and evaporated to give a crude product, which was purified using column chromatography to give the product. (0.9 g, 32%)

Provenance & Evidence