1-(2-Methoxyphenyl)piperazine → HCID 86646764, compound

HRID 404583Notes

Reaction equation

HRID 404583 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[N:9]1[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]1.ClC1C(Cl)=CC=CC=1N1CCN([CH2:29][CH2:30][CH:31]2[CH2:33][O:32]2)CC1>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[N:9]1[CH2:14][CH2:13][N:12]([CH2:29][CH2:30][CH:31]2[CH2:33][O:32]2)[CH2:11][CH2:10]1

Participants

3

Reactant 2

HCID 13461-(2-Methoxyphenyl)piperazineHCID 44203056HCID 44203056, compound

Product 1

HCID 86646764HCID 86646764, compoundYield 87%

Procedure

Prepared from 24 and 1-(2-methoxyphenyl)piperazine in a similar fashion as described above for 28a. Yield: 87%, 1H NMR (CDCl3): δ 2.60 (m, 2H), 2.67 (s, 4H), 2.78 (dd, J 4.9, 4.0), 3.00 (m, 1H), 3.10 (s, 4H), 3.86 (s, 3H), 6.86 (dd, J 7.8, 1.3, 1H), 6.88-7.03 (m, 3H). 13C NMR (CDCl3): δ 30.2, 47.2, 50.7, 51.0, 53.5, 55.2, 55.4, 111.2, 118.3, 121.1, 123.0, 141.4, 152.3.

Sources & evidence

ORD record
ord-579ae1adfa16403581b3020a5d82b905
Source dataset
uspto-grants-2014_06
Patent number
US08748608B2

Reaction notes

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