Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | 4-Oxo-1,4-dihydro-1,7-naphthyridine-3-carboxylic acid | HCID 45117420 | — |
| Reactant | HCID 57470208 | HCID 57470208 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 25225864 | HCID 25225864 | — |
Reaction Steps
To 4-oxo-1,4-dihydro-1,7-naphthyridine-3-carboxylic acid (48 mg, 0.25 mmol), 5-tert-butyl-1H-indol-6-amine (48 mg, 0.25 mmol) in DMF (1 mL) was added HATU (106 mg, 0.28 mmol), followed by triethylamine (1064, 0.76 mmol) and the reaction mixture was heated at 80° C. for 16 h. The reaction mixture was then purified by reverse phase HPLC 10-99% ACN in water to give N-(5-tert-butyl-1H-indol-6-yl)-4-oxo-1,4-dihydro-1,7-naphthyridine-3-carboxamide. MS m/z: 361.5 [M+H]+
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08748612B2 |
|---|
| Source dataset | uspto-grants-2014_06 |
|---|
| ORD ID | ord-9eb69d6a56594b9fa3b6cf2a58284496 |
|---|
| Source note | uspto-grants-2014_06 |
|---|
