反应详情

Esomeprazole (28 gm) was added to acetone (140 ml) and piperazine (8 gm) at room temperature. The reaction mixture was stirred for 1 hour at room temperature and the solid was separated. The separated solid was cooled to 10 to 15° C. and maintained for 1 hour at 10 to 15° C., filtered. The solid obtained was washed with chilled acetone and dried at 40 to 45° C. under vacuum to obtain 23 gm of esomeprazole piperazine salt.

1. customthe solid was separated
2. temperatureThe separated solid was cooled to 10 to 15° C.
3. temperaturemaintained for 1 hour at 10 to 15° C.
4. filtrationfiltered
5. customThe solid obtained
6. washwas washed with chilled acetone
7. customdried at 40 to 45° C. under vacuum