4-Methylpiperidine → HCID 86688887, compound

Participants

Reaction Steps

4-Methylpiperidine (0.17 ml, 1.48 mmol), ethyl 2-bromo-2-phenylacetate (0.22 ml, 1.23 mmol), and TEA (0.21 ml, 1.48 mmol) were dissolved in acetonitrile (6 ml) and stirred at room temperature for 48 hours. The volatiles were evaporated and the crude residue was purified by flash chromatography (petroleum ether/AcOEt=95/5) to obtain ethyl 2-(4-methylpiperidin-1-yl)-2-phenylacetate (225 mg, 69.8% yield) as a colourless oil.

Provenance & Evidence