2-Chloroacetophenone → HCID 86688892, compound

Participants

Reaction Steps

(R)-Quinuclidin-3-yl 2-phenyl-2-(pyrrolidin-1-yl)acetate (51 mg, 0.16 mmol) was dissolved in ethyl acetate (1.6 ml) and 2-chloro-1-phenylethanone (25.1 mg, 0.16 mmol) was added. The solution was stirred at room temperature for 3.5 days. The suspension was evaporated and the residue was purified by flash chromatography (DCM/MeOH=9/1 to 85/15) to obtain (3R)-1-(2-oxo-2-phenylethyl)-3-(2-phenyl-2-(pyrrolidin-1-yl)acetoxy)-1-azoniabicyclo[2.2.2]octane chloride (44 mg, 57.8% yield) as a yellow vitreous solid.

Provenance & Evidence