2-Chloroacetophenone → HCID 86688895, compound

Participants

Reaction Steps

(R)-Quinuclidin-3-yl 2-morpholino-2-phenylacetate (43 mg, 0.13 mmol) was dissolved in ethyl acetate (1.3 ml) and 2-chloro-1-phenylethanone (22.1 mg, 0.14 mmol) was added. The solution was stirred at room temperature for two days. The solvent was evaporated and the residue was triturated with Et2O to obtain (3R)-3-(2-morpholino-2-phenylacetoxy)-1-(2-oxo-2-phenylethyl)-1-azoniabicyclo[2.2.2]octane chloride (53 mg, 84% yield) as a pale yellow solid.

Provenance & Evidence