2-Chloroacetophenone → HCID 86688906, compound

Participants

Reaction Steps

(R)-Quinuclidin-3-yl 2-(4-acetylpiperazin-1-yl)-2-phenylacetate (210 mg, 0.56 mmol) was dissolved in a mixture EtOAc (3.8 ml) and acetonitrile (1.8 ml). 2-Chloro-1-phenylethanone (96 mg, 0.62 mmol) was added and the reaction was stirred at room temperature for 16 hours. The solvent was evaporated and the crude was purified by flash chromatography (DCM/MeOH=9/1) to obtain (3R)-3-(2-(4-acetylpiperazin-1-yl)-2-phenylacetoxy)-1-(2-oxo-2-phenylethyl)-1-azoniabicyclo[2.2.2]octane chloride (178 mg, 59.9% yield) as an off-white spongy solid.

Provenance & Evidence