2-Chloroacetophenone → HCID 86688910, compound

Participants

Reaction Steps

(R)-Quinuclidin-3-yl 2-(4-carbamoylpiperidin-1-yl)-2-phenylacetate (72 mg, 0.19 mmol) was dissolved in a mixture EtOAc (1.3 ml) and acetonitrile (0.6 ml). 2-Chloro-1-phenylethanone (33.0 mg, 0.21 mmol) was added and the mixture was reacted at the same temperature for three days. The mixture was evaporated and the crude was purified by flash chromatography (DCM/MeOH=85/15 to 8/2) to obtain (3R)-3-(2-(4-carbamoylpiperidin-1-yl)-2-phenylacetoxy)-1-(2-oxo-2-phenylethyl)-1-azoniabicyclo[2.2.2]octane chloride (34 mg, 33.3% yield) as a pale yellow solid.

Provenance & Evidence